Where Einstein Meets Edison

Navigating Biotech Adolescence

Navigating Biotech Adolescence

Mar 29, 2011

Merrimack Pharmaceuticals is a Cambridge-based biotechnology company with a promising pipeline of monoclonal and multi-specific antibodies for cancer and autoimmune disease. Merrimack distinguishes itself by incorporating systems-level mathematical modeling, what the company calls Network Biology, in its choice of targets and design of therapeutics. For example,...

Can Adimab revive the monoclonal antibody?

Can Adimab revive the monoclonal antibody?

Jan 19, 2011

The therapeutic development of monoclonal antibodies – the poster child of the biologics revolution – was supposed to herald a new, modern age in which genomic data would identify proteins involved in disease and genetic engineering would produce new molecules against these targets. Much of this scenario has come true: genomics frequently steers...

Entrepreneurial opportunities and challenges in the search for an HIV vaccine

Entrepreneurial opportunities and challenges in the search for an HIV vaccine

Nov 24, 2010

In an episode of the animated television comedy South Park, scientists discover that the reason former professional basketball player Magic Johnson has survived so long with HIV without developing AIDS is that he sleeps on a giant pile of money. Irreverent humor aside, there is a substantial vein of truth to this joke. In developed countries, where patients are...